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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
TWF2_HUMAN
USC-OGP 2-DE database
:
TWF2_HUMAN
TWF2_HUMAN
General information about the entry
View entry in simple text format
Entry name
TWF2_HUMAN
Primary accession number
Q6IBS0
Secondary accession number(s)
Q9Y3F5
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Twinfilin-2; AltName: Full=A6-related protein; Short=hA6RP; AltName: Full=Protein tyrosine kinase 9-like; AltName: Full=Twinfilin-1-like protein;.
Gene name
Name=TWF2
Synonyms=PTK9L
ORFNames=MSTP011
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0432
:
pI=6.42; Mw=40313
PLATELET_6-11
{PLATELET 6-11}
Homo sapiens (Human)
map experimental info
PLATELET_6-11
MAP LOCATIONS:
SPOT OGP-0955
:
pI=6.32; Mw=40359
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1171
:
pI=4.97; Mw=46576
SPOT OGP-1195
:
pI=6.77; Mw=40578
Cross-references
UniProtKB/Swiss-Prot
Q6IBS0; TWF2_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
TWF2_HUMAN
Primary accession number
Q6IBS0
Secondary accession number(s)
Q9Y3F5
Sequence was last modified on
May 2, 2006 (version 2)
Annotations were last modified on
March 15, 2017 (version 124)
Name and origin of the protein
Description
RecName: Full=Twinfilin-2; AltName: Full=A6-related protein; Short=hA6RP; AltName: Full=Protein tyrosine kinase 9-like; AltName: Full=Twinfilin-1-like protein;
Gene name
Name=TWF2
Synonyms=PTK9L
ORFNames=MSTP011
Encoded on
Name=TWF2; Synonyms=PTK9L; ORFNames=MSTP011
Keywords
3D-structure
;
Acetylation
;
Actin-binding
;
Cell projection
;
Cilium biogenesis/degradation
;
Complete proteome
;
Cytoplasm
;
Cytoskeleton
;
Direct protein sequencing
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
Repeat
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
Y17169; CAB38055.1
; -; mRNA
EMBL
AL136773; CAB66707.1
; -; mRNA
EMBL
AF109365; AAQ13513.1
; -; mRNA
EMBL
CR456732; CAG33013.1
; -; mRNA
EMBL
CR533520; CAG38551.1
; -; mRNA
EMBL
BC000327; AAH00327.1
; -; mRNA
EMBL
BC003161; AAH03161.1
; -; mRNA
EMBL
BC016452; AAH16452.1
; -; mRNA
CCDS
CCDS2849.1; -
; .
PIR
T46362; T46362
; .
RefSeq
NP_009215.1; NM_007284.3
; .
UniGene
Hs.436439; -
; .
PDB
2VAC; X-ray
; 1.70 A; A=6-137
PDB
2W0I; X-ray
; 1.80 A; A=181-313
PDBsum
2VAC; -
; .
PDBsum
2W0I; -
; .
ProteinModelPortal
Q6IBS0; -
; .
SMR
Q6IBS0; -
; .
BioGrid
116472; 63
; .
IntAct
Q6IBS0; 14
; .
MINT
MINT-1414584; -
; .
STRING
9606.ENSP00000303908; -
; .
iPTMnet
Q6IBS0; -
; .
PhosphoSitePlus
Q6IBS0; -
; .
SwissPalm
Q6IBS0; -
; .
BioMuta
TWF2; -
; .
DMDM
94730596; -
; .
OGP
Q9Y3F5; -
; .
EPD
Q6IBS0; -
; .
MaxQB
Q6IBS0; -
; .
PaxDb
Q6IBS0; -
; .
PeptideAtlas
Q6IBS0; -
; .
PRIDE
Q6IBS0; -
; .
DNASU
11344; -
; .
Ensembl
ENST00000305533; ENSP00000303908
; ENSG00000247596; .
GeneID
11344; -
; .
KEGG
hsa:11344; -
; .
UCSC
uc003ddd.4; human
; .
CTD
11344; -
; .
GeneCards
TWF2; -
; .
HGNC
HGNC:9621; TWF2
; .
HPA
HPA053874; -
; .
MIM
607433; gene
; .
neXtProt
NX_Q6IBS0; -
; .
OpenTargets
ENSG00000247596; -
; .
PharmGKB
PA162407429; -
; .
eggNOG
KOG1747; Eukaryota
; .
eggNOG
ENOG410XS1J; LUCA
; .
GeneTree
ENSGT00530000063868; -
; .
HOGENOM
HOG000168296; -
; .
HOVERGEN
HBG000848; -
; .
InParanoid
Q6IBS0; -
; .
KO
K08870; -
; .
OMA
IRLIKVI; -
; .
OrthoDB
EOG091G0BWK; -
; .
PhylomeDB
Q6IBS0; -
; .
TreeFam
TF352598; -
; .
EvolutionaryTrace
Q6IBS0; -
; .
GeneWiki
TWF2; -
; .
GenomeRNAi
11344; -
; .
PRO
PR:Q6IBS0; -
; .
Proteomes
UP000005640; Chromosome 3
; .
Bgee
ENSG00000247596; -
; .
CleanEx
HS_TWF2; -
; .
ExpressionAtlas
Q6IBS0; baseline and differential
; .
Genevisible
Q6IBS0; HS
; .
GO
GO:0005737; C:cytoplasm
; NAS:UniProtKB; .
GO
GO:0005856; C:cytoskeleton
; IEA:UniProtKB-SubCell; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0030175; C:filopodium
; ISS:BHF-UCL; .
GO
GO:0030426; C:growth cone
; IDA:BHF-UCL; .
GO
GO:0030027; C:lamellipodium
; ISS:BHF-UCL; .
GO
GO:0030016; C:myofibril
; ISS:BHF-UCL; .
GO
GO:0048471; C:perinuclear region of cytoplasm
; ISS:BHF-UCL; .
GO
GO:0032420; C:stereocilium
; ISS:BHF-UCL; .
GO
GO:0003785; F:actin monomer binding
; ISS:BHF-UCL; .
GO
GO:0005524; F:ATP binding
; IDA:UniProtKB; .
GO
GO:0045296; F:cadherin binding
; IDA:BHF-UCL; .
GO
GO:0005546; F:phosphatidylinositol-4
; 5-bisphosphate binding; ISS:BHF-UCL
GO
GO:0005080; F:protein kinase C binding
; IPI:BHF-UCL; .
GO
GO:0003723; F:RNA binding
; IDA:UniProtKB; .
GO
GO:0051016; P:barbed-end actin filament capping
; ISS:BHF-UCL; .
GO
GO:0030030; P:cell projection organization
; IEA:UniProtKB-KW; .
GO
GO:0071363; P:cellular response to growth factor stimulus
; IMP:BHF-UCL; .
GO
GO:0071300; P:cellular response to retinoic acid
; IMP:BHF-UCL; .
GO
GO:0030837; P:negative regulation of actin filament polymerization
; ISS:BHF-UCL; .
GO
GO:0045773; P:positive regulation of axon extension
; IMP:BHF-UCL; .
GO
GO:0010592; P:positive regulation of lamellipodium assembly
; IMP:BHF-UCL; .
GO
GO:0010976; P:positive regulation of neuron projection development
; IMP:BHF-UCL; .
GO
GO:0032956; P:regulation of actin cytoskeleton organization
; IMP:BHF-UCL; .
GO
GO:0032532; P:regulation of microvillus length
; IC:BHF-UCL; .
GO
GO:0042989; P:sequestering of actin monomers
; ISS:BHF-UCL; .
Gene3D
3.40.20.10; -
; 2; .
InterPro
IPR002108; ADF-H
; .
InterPro
IPR029006; ADF-H/Gelsolin-like_dom
; .
InterPro
IPR028458; Twinfilin
; .
PANTHER
PTHR13759; PTHR13759
; 1; .
Pfam
PF00241; Cofilin_ADF
; 2; .
SMART
SM00102; ADF
; 2; .
PROSITE
PS51263; ADF_H
; 2; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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