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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: TWF2_HUMAN




USC-OGP 2-DE database:  TWF2_HUMAN


TWF2_HUMAN


General information about the entry
View entry in simple text format
Entry nameTWF2_HUMAN
Primary accession numberQ6IBS0
Secondary accession number(s) Q9Y3F5
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Twinfilin-2; AltName: Full=A6-related protein; Short=hA6RP; AltName: Full=Protein tyrosine kinase 9-like; AltName: Full=Twinfilin-1-like protein;.
Gene nameName=TWF2
Synonyms=PTK9L
ORFNames=MSTP011
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=6.42; Mw=40313



PLATELET_6-11 {PLATELET 6-11}
Homo sapiens (Human)
PLATELET_6-11
  map experimental info
 
PLATELET_6-11

MAP LOCATIONS:
pI=6.32; Mw=40359



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=4.97; Mw=46576
pI=6.77; Mw=40578

Cross-references
UniProtKB/Swiss-ProtQ6IBS0; TWF2_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameTWF2_HUMAN
Primary accession numberQ6IBS0
Secondary accession number(s) Q9Y3F5
Sequence was last modified on May 2, 2006 (version 2)
Annotations were last modified on March 15, 2017 (version 124)
Name and origin of the protein
DescriptionRecName: Full=Twinfilin-2; AltName: Full=A6-related protein; Short=hA6RP; AltName: Full=Protein tyrosine kinase 9-like; AltName: Full=Twinfilin-1-like protein;
Gene nameName=TWF2
Synonyms=PTK9L
ORFNames=MSTP011
Encoded onName=TWF2; Synonyms=PTK9L; ORFNames=MSTP011
Keywords3D-structure; Acetylation; Actin-binding; Cell projection; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLY17169; CAB38055.1; -; mRNA
EMBLAL136773; CAB66707.1; -; mRNA
EMBLAF109365; AAQ13513.1; -; mRNA
EMBLCR456732; CAG33013.1; -; mRNA
EMBLCR533520; CAG38551.1; -; mRNA
EMBLBC000327; AAH00327.1; -; mRNA
EMBLBC003161; AAH03161.1; -; mRNA
EMBLBC016452; AAH16452.1; -; mRNA
CCDSCCDS2849.1; -; .
PIRT46362; T46362; .
RefSeqNP_009215.1; NM_007284.3; .
UniGeneHs.436439; -; .
PDB2VAC; X-ray; 1.70 A; A=6-137
PDB2W0I; X-ray; 1.80 A; A=181-313
PDBsum2VAC; -; .
PDBsum2W0I; -; .
ProteinModelPortalQ6IBS0; -; .
SMRQ6IBS0; -; .
BioGrid116472; 63; .
IntActQ6IBS0; 14; .
MINTMINT-1414584; -; .
STRING9606.ENSP00000303908; -; .
iPTMnetQ6IBS0; -; .
PhosphoSitePlusQ6IBS0; -; .
SwissPalmQ6IBS0; -; .
BioMutaTWF2; -; .
DMDM94730596; -; .
OGPQ9Y3F5; -; .
EPDQ6IBS0; -; .
MaxQBQ6IBS0; -; .
PaxDbQ6IBS0; -; .
PeptideAtlasQ6IBS0; -; .
PRIDEQ6IBS0; -; .
DNASU11344; -; .
EnsemblENST00000305533; ENSP00000303908; ENSG00000247596; .
GeneID11344; -; .
KEGGhsa:11344; -; .
UCSCuc003ddd.4; human; .
CTD11344; -; .
GeneCardsTWF2; -; .
HGNCHGNC:9621; TWF2; .
HPAHPA053874; -; .
MIM607433; gene; .
neXtProtNX_Q6IBS0; -; .
OpenTargetsENSG00000247596; -; .
PharmGKBPA162407429; -; .
eggNOGKOG1747; Eukaryota; .
eggNOGENOG410XS1J; LUCA; .
GeneTreeENSGT00530000063868; -; .
HOGENOMHOG000168296; -; .
HOVERGENHBG000848; -; .
InParanoidQ6IBS0; -; .
KOK08870; -; .
OMAIRLIKVI; -; .
OrthoDBEOG091G0BWK; -; .
PhylomeDBQ6IBS0; -; .
TreeFamTF352598; -; .
EvolutionaryTraceQ6IBS0; -; .
GeneWikiTWF2; -; .
GenomeRNAi11344; -; .
PROPR:Q6IBS0; -; .
ProteomesUP000005640; Chromosome 3; .
BgeeENSG00000247596; -; .
CleanExHS_TWF2; -; .
ExpressionAtlasQ6IBS0; baseline and differential; .
GenevisibleQ6IBS0; HS; .
GOGO:0005737; C:cytoplasm; NAS:UniProtKB; .
GOGO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0030175; C:filopodium; ISS:BHF-UCL; .
GOGO:0030426; C:growth cone; IDA:BHF-UCL; .
GOGO:0030027; C:lamellipodium; ISS:BHF-UCL; .
GOGO:0030016; C:myofibril; ISS:BHF-UCL; .
GOGO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL; .
GOGO:0032420; C:stereocilium; ISS:BHF-UCL; .
GOGO:0003785; F:actin monomer binding; ISS:BHF-UCL; .
GOGO:0005524; F:ATP binding; IDA:UniProtKB; .
GOGO:0045296; F:cadherin binding; IDA:BHF-UCL; .
GOGO:0005546; F:phosphatidylinositol-4; 5-bisphosphate binding; ISS:BHF-UCL
GOGO:0005080; F:protein kinase C binding; IPI:BHF-UCL; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0051016; P:barbed-end actin filament capping; ISS:BHF-UCL; .
GOGO:0030030; P:cell projection organization; IEA:UniProtKB-KW; .
GOGO:0071363; P:cellular response to growth factor stimulus; IMP:BHF-UCL; .
GOGO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL; .
GOGO:0030837; P:negative regulation of actin filament polymerization; ISS:BHF-UCL; .
GOGO:0045773; P:positive regulation of axon extension; IMP:BHF-UCL; .
GOGO:0010592; P:positive regulation of lamellipodium assembly; IMP:BHF-UCL; .
GOGO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL; .
GOGO:0032956; P:regulation of actin cytoskeleton organization; IMP:BHF-UCL; .
GOGO:0032532; P:regulation of microvillus length; IC:BHF-UCL; .
GOGO:0042989; P:sequestering of actin monomers; ISS:BHF-UCL; .
Gene3D3.40.20.10; -; 2; .
InterProIPR002108; ADF-H; .
InterProIPR029006; ADF-H/Gelsolin-like_dom; .
InterProIPR028458; Twinfilin; .
PANTHERPTHR13759; PTHR13759; 1; .
PfamPF00241; Cofilin_ADF; 2; .
SMARTSM00102; ADF; 2; .
PROSITEPS51263; ADF_H; 2; .



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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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